epithelial cancer — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3862	Irigenin		NF-κB , Integrin
	Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enha...		NF-κB , Integrin
T41286	N6-Isopentenyladenosine		Endogenous Metabolite , Autophagy
	N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity. N6-Isopentenyladenosine, an RNA modification found in cytokinins, regulates plant growth/different...		Endogenous Metabolite , Autophagy
T4S0969	Obtusifolin		Antioxidant , NF-κB
	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...		Antioxidant , NF-κB
T5S1882	Songorine	Napellonine,Zongorine,Bullatine G	Others , GABA Receptor
	Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.		Others , GABA Receptor
T0459	Sulindac	Arthrocine,MK-231,Clinoril,Sulindac sulfoxide	COX , Autophagy
	Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl...		COX , Autophagy
T4102	Goserelin acetate	Fertilan,ICI-118630 acetate,Zoladex	Apoptosis , GNRH Receptor
	Goserelin acetate (Fertilan) is a synthetic long-acting agonist of gonadotropin-releasing hormone, used in treatments of cancer.		Apoptosis , GNRH Receptor
T17216	Valspodar	PSC 833	P-gp
	Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.		P-gp
T24997	ABT-510 acetate	ABT 510 acetate	Apoptosis
	ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth i...		Apoptosis
TN1433	Batatasin III		FAK , Others , Akt
	Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-...		FAK , Others , Akt
T4869	D-Allose	β-D-Allopyranose,D-(+)-ALLOSE	Others , Endogenous Metabolite
	D-Allose (β-D-Allopyranose) is a rare naturally occurring monosaccharide known to exert anti-proliferative effects on cancer cells. The effects of D-Allose on the cellular membranes of hormone-refractory prostate cancer ...		Others , Endogenous Metabolite
T7982	3,6-Dihydroxyflavone		Others
	3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.		Others
T77701	FL118	FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin	Survivin
	FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/β-catenin s...		Survivin
T11793	KY-05009		Wnt/beta-catenin
	KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o...		Wnt/beta-catenin
T73300	AXL-IN-13		FLT , TAM Receptor , PDGFR , TGF-beta/Smad
	AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and inh...		FLT , TAM Receptor , PDGFR , TGF-beta/Smad
T38752	EW-7195		ALK , TGF-beta/Smad
	EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-i...		ALK , TGF-beta/Smad
TP1565L1	Foxy-5 Ammonium Salt	Foxy-5 Ammonium Salt（881188-51-8 Free base)	Wnt/beta-catenin
	Foxy-5 Ammonium Salt is a WNT5A agonist, a mimetic peptide of WNT5A, a non-classical member of the Wnt family.Foxy-5 Ammonium Salt triggers cytoplasmic free calcium signaling without affecting β-catenin activation and in...		Wnt/beta-catenin
T19710	Ciglitazone	Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878	Apoptosis , p38 MAPK , PPAR
	Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelia...		Apoptosis , p38 MAPK , PPAR
T3123	Allicin		ERK , IL Receptor , Others , IκB/IKK , p38 MAPK , TNF , ROS , Caspase , Antifection
	Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus...
T35749	Thymohydroquinone	Thymoquinol	Antioxidant , Reactive Oxygen Species
	Thymohydroquinone (Thymoquinol) is a monoterpenoid phenolic compound found in thyme, oregano, and other plants in the labiaceae family. Thymohydroquinone inhibits cancer cell growth, reduces oxidative stress and modulate...		Antioxidant , Reactive Oxygen Species
T4S0797	Berberine	Berberin,Umbellatine	Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy
	1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3....